We present here an approach to protein design that combines (i) scarce functional information such as experimental data (ii) evolutionary information learned from a natural sequence variants and (iii) physics-grounded modeling. Using a Restricted Boltzmann Machine (RBM). we learn a sequence model of a protein family. We use semi-supervision to leverage available functional information... https://www.jmannino.com/quick-sale-Catherine-Lansfield-Ombre-Rainbow-Clouds-66x72-Ready-Made-Eyelet-Curtains-Pastel-big-sale/