The depth and versatility of siRNA technologies enable their use in disease targets that are undruggable by small molecules or that seek to achieve a refined turn-off of the genes for any therapeutic area. Major extracellular barriers are enzymatic degradation of siRNAs by serum endonucleases and RNAases. renal clearance of the siRNA delivery system. the impermeability of biological m... https://www.roneverhart.com/AMS-Neve-1073SPX-Single-Preamp-and-EQ-p33827/